논문검색
Author Hee Jung Sohn, Sang Hee Kim, Gyeong Won Lee, Shin Kim, Jin Hee Ahn, Sung Bae Kim, Sang We Kim, Woo Kun Kim, Cheolwon Suh
Place of duty Department of Internal Medicine, 1University of Ulsan College of Medicine, Asan Medical Center, Seoul, 2Gyeongsang National University Hospital, Jinju, Korea.
Title High-Dose Chemotherapy of Cyclophosphamide, Thiotepa and Carboplatin (CTCb) followed by Autologous Stem-Cell Transplantation as a Consolidation for Breast Cancer Patients with 10 or more Positive Lymph Nodes: a 5-Year follow-Up Results
Publicationinfo Cancer Res Treat. 2005 Jun; 037(03): 137-142.
Key_word Breast Neoplasms,Peripheral blood stem cell transplantation,Cyclophosphamide,Thiotepa,Carboplatin,Consolidation
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Abstract Purpose: The benefit of consolidation high-dose chemotherapy (HDC) for high-risk primary breast cancer is controversial. We evaluated the efficacy and safety of consolidation HDC with cyclophosphamide, thiotepa and carboplatin (CTCb) followed by autologous stem-cell transplantation (ASCT) in resected breast cancer patients with 10 or more positive lymph nodes. Materials and Methods: Between December 1994 and April 2000, 22 patients were enrolled. All patients received 2 to 6 cycles of adjuvant chemotherapy after surgery for breast cancer. The HDC regimen consisted of cyclophosphamide 1,500 mg/m2/day, thiotepa 125 mg/m2/day and carboplatin 200 mg/m2/day intravenous for 4 consecutive days. Results: With a median follow-up of 58 months, 11 patients recurred and died. The median disease-free survival (DFS) and median overall survival (OS) were 49 and 69 months, respectively. The 5-year DFS and OS rates were 50% and 58%, respectively. The 12 patients with 10 to 18 involved nodes had better 5-year DFS (67%) and OS (75%) than 10 patients with more than 18 involved nodes (30% and 38%, respectively). The most common grade 3 or 4 nonhematologic toxicity was diarrhea, which occurred in 5 patients (23%). No treatment-related death was observed. Conclusion: Consolidation HDC with CTCb followed by ASCT for resected breast cancer with more than 10 positive nodes had an acceptable toxicity but does not show promising survival. (Cancer Res Treat. 2005;37:137-142)